Hayflick
Hayflick
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No Limits

Who We Are

Hayflick Therapeutics is a development-stage biotechnology company advancing the proven use of rapamycin through disciplined, FDA-aligned innovation.

Positioned at the intersection of aesthetics and healthspan, Hayflick is advancing a first-in-class platform targeting the mTOR pathway to bring cellular aging interventions to a broad and underserved global market.

Through localized, micro-dose delivery, our platform enables root cause, molecular-level aging intervention that is safe, measurable, patent-protected, and designed for FDA approval.

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The Hayflick Story

Built on six decades of scientific discovery, the Hayflick story traces the evolution of our understanding of cellular aging. What began as a groundbreaking observation about how human cells divide has grown into a foundational concept that continues to shape modern research into longevity and cellular health.

Easter Island

Discovery & Early Promise

1964–1999

Rapamycin was discovered in soil samples taken from the island of Rapa Nui in 1964.

First patented as an immunosuppressant, it was later identified as a suppressor of mTOR—a master regulator of cellular growth. The drug was approved by the FDA in 1999 under the brand name Rapamune to prevent graft rejection in kidney transplant patients.

Proof, With Limits

2009–2015

Landmark research demonstrated that suppressing mTOR could influence aging pathways.

Rapamycin became one of the most studied compounds in aging biology, establishing a rare foundation of rigorous clinical and mechanistic evidence.

Dr. Christian Sell demonstrated that very low doses of rapamycin prevent cellular aging. However, systemic dosing in humans carried toxicity risks.

With expired patents and safety concerns, commercial progress slowed. The biology was compelling but toxicity issues remained unresolved.

Water

Current Focus

2015–Present

Dr. Sell shifted his focus to the potential of topical rapamycin as a treatment for aged cells in the skin.

With dermatologist Dr. Christina Lee Chung, he pursued a defining question: could mTOR suppression be localized safely and effectively in human skin? The result was a breakthrough and marked the formation of Hayflick Therapeutics.

The founding team developed a topical, micro-dose formulation that made mTOR suppression stable, measurable, and free of systemic exposure. This work established a credible path toward reversing markers of cellular aging in a human organ, advancing cellular health with clinical precision.

The company secured global intellectual property protection covering low-dose topical mTOR inhibition, including method of use and classwide protection.

The Future

What's Next

Hayflick is now pursuing a first-in-class FDA approval, with a projected regulatory pathway targeting 2031.

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Our Mission
Advancinga
NewEraOf Anti-AgingHealthspan
ByResponsibly Elasticity
PioneeringTheProven
Well-BeingUseOfRapamycin.
Advancinga
New
Eraof Anti-Aging
Healthspan
By
Responsibly
Pioneering
ElasticityThe
Proven
Use Well-BeingOf
Rapamycin
Our Team

Rigorous Science &
Boundless Vision

Clinician-scientists, biotech operators, and regulatory experts translating longevity biology into disciplined, FDA-aligned therapeutics.

Co-founders

Christina Lee Chung, MD, FAAD
Christina Lee Chung, MD, FAAD
CEO

Board-certified dermatologist and former Drexel Associate Professor. Internationally recognized expertise in skin cancer developing in organ transplant recipients with groundbreaking publications identifying key risk factors in patients of color. Dr. Chung's work provides extensive experience with mTOR inhibitors. She is co-author of the 2019 Geroscience study demonstrating that topical rapamycin reduces markers of cellular aging in human skin. Dr. Chung helped establish the clinical evidence that makes longevity science credible in dermatology. At Hayflick, she leads with the same discipline she brings to her research: no hype, no shortcuts, no apology for the ambition.

Christian Sell, PhD
Christian Sell, PhD
Chief Scientific Officer

Professor at Drexel University and director of its Aging Initiative. For more than fifteen years, he has studied the biological boundary where cells stop dividing, and what it would take to extend it. Dr. Sell’s research in mTOR biology forms a foundational pillar of Hayflick’s scientific strategy. At Hayflick, he applies deep mechanistic expertise to translate cellular aging science into measurable therapeutic progress.

Bernadette Hitt, MBA
Bernadette Hitt, MBA
President

With a background in executive leadership at Tiffany & Co. and Cartier, Bernadette brings deep experience building globally trusted luxury brands. She specializes in aligning operations, narrative, and execution at scale – an expertise she recently applied to the indie beauty sector, where she professionalized a growth start-up’s operations and sharpened its premium identity for commercial scale. At Hayflick, Bernadette translates complex science into strategic clarity—building the partnerships, structure, and positioning required for long-term growth.

Mike Rafa, JD
Mike Rafa, JD
Chief Counsel

Biotech executive and intellectual property attorney with extensive experience in biotech and pharmaceutical IP and licensing strategy, ANDA litigation and lifecycle management. Mike has guided therapeutics through complex commercial and legal landscapes, protecting innovation and enabling durable partnerships. At Hayflick, he ensures that breakthrough biology is strategically protected and positioned for sustained value creation.

Scientific Advisory Board

Sarah Arron, MD, PhD
Sarah Arron, MD, PhD

Board-certified dermatologist and fellowship-trained Mohs micrographic surgeon with over fifteen years of experience in dermatologic surgery and aesthetic dermatology. She trained at UCSF and served on faculty for twelve years, leading translational skin cancer research and holding senior clinical leadership roles. At Hayflick, she provides guidance on dermatologic strategy and the clinical integration of emerging therapeutics.

Matt Kaeberlein, PhD
Matt Kaeberlein, PhD

Biologist and biogerontologist widely recognized for pioneering research on evolutionarily conserved mechanisms of aging. Matt is the founder and CEO of Optispan, a proactive health platform focused on science-based preventative medicine, and Co-Director of the Dog Aging Project, one of the largest longitudinal studies of aging in companion animals. His work explores how longevity interventions influence healthspan across species. At Hayflick, he provides scientific guidance on aging biology and the translation of longevity research into clinical applications.

Brian Kennedy, PhD
Brian Kennedy, PhD

Distinguished Professor at the National University of Singapore and Director of the Centre for Healthy Longevity. He previously served as President and CEO of the Buck Institute for Research on Aging, one of the world’s leading institutions in aging science. His work focuses on translating longevity research into measurable human health outcomes. At Hayflick, he provides strategic guidance on translational science and long-term scientific direction.

Drug Development

Pericles Calias, PhD
Pericles Calias, PhD

Pharmaceutical development scientist with over twenty-five years of experience in FDA submissions, CMC and regulatory strategy. Dr. Calias has navigated the path from compound to approval across multiple therapeutic modalities. At Hayflick, he ensures that scientific ambition is matched by regulatory precision and executional reality.

Perspectives

Conversations, Research,
and Media Shaping
the future of Cellular Aging

  • Featured in MIT Breakthrough Technologies

    Featured in MIT Breakthrough Technologies

    Featured in MIT Breakthrough Technologies

    Featured in MIT’s annual list of technological advances...

    Featured in MIT’s annual list of technological advances...

  • Rapamycin Cream May Slow Ageing in Skin: Study

    Rapamycin Cream May Slow Ageing in Skin: Study

    Rapamycin Cream May Slow Ageing in Skin: Study

    The study, published in the journal Geroscience, is the first to show an effect on ageing in human tissue, specifically skin in which signs of ageing were reduced.

    The study, published in the journal Geroscience, is the first to show an effect on ageing in human tissue, specifically skin in which signs of ageing were reduced.

  • Trial Results Published in GeroScience

    Trial Results Published in GeroScience

    Trial Results Published in GeroScience

    Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial

    Christina Lee Chung, MD, FAAD

    Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial

    Christina Lee Chung, MD, FAAD
  • Aging Cell Study: mTOR, Rapamycin, Longevity

    Aging Cell Study: mTOR, Rapamycin, Longevity

    Aging Cell Study: mTOR, Rapamycin, Longevity

    A publication by Lerner et al shows the prevention of senescence in human cells when treated with rapamycin...

    Christian Sell, PhD

    A publication by Lerner et al shows the prevention of senescence in human cells when treated with rapamycin...

    Christian Sell, PhD
  • Connect

    Partner With Us

    A new standard in healthspan. Evidence-led and built to endure. For investor inquiries and strategic collaborations email us at info@hayflicktx.com.